131 documentos corresponden a la consulta.
Palabras contadas: unclassified: 131, drug: 315
Sintas, J.A. - Macareno, N.J. - Vitale, A.A.
Molecules 2000;5(3):526-528
2000
Temas: 8 dihydroxyborylharmine b 10 - radiopharmaceutical agent - unclassified drug - animal tissue - autoradiography - binding site - conference paper - drug distribution - drug structure - drug synthesis
Descripción: We have described a method for preparation of [10B]-enriched-8- dihydroxyborylharmine (III) and characterized it by their spectral properties (MS, IR and NMR). This compound is a potential BNCT agent.
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Zorreguieta, A. - Ugalde, R.A.
J. BACTERIOL. 1986;167(3):947-951
1986
Temas: beta 1,2 glucan - polysaccharide - protein - unclassified drug - article - nonhuman - Rhizobium - Agrobacterium - Rhizobium
Descripción: Fil:Zorreguieta, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
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Díaz De Vivar, M.E. - Maier, M.S. - Seldes, A.M.
Molecules 2000;5(3):350-351
2000
Temas: labidiasteroside a - saponin - unclassified drug - Asterias - conference paper - drug isolation - drug structure - Labidiaster annulatus - nonhuman - structure analysis
Descripción: Purification of the ethanolic extract of the starfish L. annulatus led to the isolation of two sulfated glycosides and a pentahydroxylated steroid. One of the saponins contains a novel pentasaccharide chain attached to C-6 of the steroidal aglycone.
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Urbina, J.A. - Concepcion, J.L. - Montalvetti, A. - Rodriguez, J.B. - Docampo, R.
Antimicrob. Agents Chemother. 2003;47(6):2047-2050
2003
Temas: 4 phenoxyphenoxyethyl thiocyanate - antiprotozoal agent - squalene synthase - sterol - unclassified drug - wc 9 - antiprotozoal activity - article - Chagas disease - controlled study
Descripción: We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase.
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Bellozas Reinhard, M.E. - Licastrode, S.A.
Molecules 2000;5(3):602-604
2000
Temas: acetylcholinesterase - insecticide - organophosphorus compound - sulfoximine - unclassified drug - computer simulation - conference paper - infrared radiation - insecticidal activity - measurement
Descripción: New organophosphorus insecticides of dialkylsulphoximines derived with activity upon acetylcholinesterase were synthesized. The obtained compounds were characterized by NMR and IR, and anticholinesterase activity and toxicity was measured. A simulation through computer was done in order to establish the relationship between structure and activity.
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Di Chenna, P. - Ghini, A.A. - Burton, G.
Molecules 2000;5(3):447-448
2000
Temas: 11alpha hydroxyprogesterone - 3alpha hydroxy 5alpha pregnan 20 one derivative - cyclopropylketone derivative - dehydropregnenolone acetate - ketone derivative - mercury derivative - neurosteroid derivative - pregnenolone derivative - steroid - unclassified drug
Descripción: 17(13→18)-Abeo and D-homo analogs of the natural neurosteroid 3α-hydroxy-5αH-pregnan-20-one were prepared by anionic or radical (mercury (II) hydride mediated) rearrangements of steroidal cyclopropylketones respectively.
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Martinez Esperón, M.F. - Fascio, M.L. - D'Accorso, N.B.
Molecules 2000;5(3):418-419
2000
Temas: 3 (1',2' o isopropylidene alpha dextro xylofuranos 4' yl) 5 phenyl 2 isoxazole - carbohydrate derivative - heterocyclic compound - isoxazole derivative - unclassified drug - carbon nuclear magnetic resonance - conference paper - cycloaddition - drug activity - drug synthesis
Descripción: The synthesis of some isoxazolic compounds from carbohydrate derivatives is described. These products are obtained by 1,3-dipolar cycloaddition reaction and their functionalization leads to derivatives with potential biological activities.
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Rodrígues-Poveda, C.A. - González-Pacanowska, D. - Szajnman, S.H. - Rodríguez, J.B.
Antimicrob. Agents Chemother. 2012;56(8):4483-4486
2012
Temas: 1,1 bisphosphonic acid derivative - bisphosphonic acid derivative - geranyltransferase - squalene synthase - squalene synthase inhibitor - unclassified drug - article - drug effect - drug mechanism - drug potency
Descripción: As part of our efforts aimed at searching for new antiparasitic agents, the effect of representative 2-alkylaminoethyl-1,1-bisphosphonic acids on Trypanosoma cruzi squalene synthase (TcSQS) was investigated. These compounds had proven to be potent inhibitors of T. cruzi. This cellular activity had been associated with an inhibition of the enzymatic activity of T. cruzi farnesyl diphosphate synthase. 2-Alkylaminoethyl-1,1-bisphosphonic acids appear to have a dual action, since they also inhibit TcSQS at the nanomolar range. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
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Bertinetti, B.V. - Rodriguez, M.A. - Godeas, A.M. - Cabrera, G.M.
J. Antibiot. 2010;63(11):681-683
2010
Temas: 3,3'-biindolyl - biindole - epipolythiodioxopiperazines - ETP - Gliocladium catenulatum - trioxopiperazines - 1h, 1'h [3,3]biindolyl - antiinfective agent - unclassified drug - agar diffusion
Descripción: Fil:Bertinetti, B.V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
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Eduardo, S.L. - Ghini, A.A. - Burton, G.
Arkivoc 2003;2003(10):468-476
2003
Temas: 2,19-Oxido-allopregnanolone - 4,19-oxido-allopregnanolone - Neurosteroid - Oxido-bridged steroid - 19 hydroxy 2alpha,3alpha epoxypregnane - 19 hydroxypregnenolone 3 acetate - 3alpha hydroxy 2,19 oxido 5alphah pregnan 20 one - 3alpha hydroxy 5alphah pregnan 20 one - 4beta,19 oxido 3alpha hydroxy 5alphah pregnan 20 one - bridged compound
Descripción: 3α-Hydroxy-2,19-oxido-5αH-pregnan-20-one was synthesized in 6 steps from the easily available 19-hydroxypregnenolone 3-acetate. The 2,19-oxido bridge was formed in a single step upon spontaneous cyclization and desilylation of a TBDMS protected 19-hydroxy-2α,3α-epoxypregnane. The 4,19-oxido analogue was obtained as a byproduct upon cyclization of the isomeric 3α,4α-epoxide.
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Cirigliano, A.M. - Veleiro, A.S. - Oberti, J.C. - Burton, G.
Molecules 2000;5(3):441-442
2000
Temas: jaborosa odonelliana extract - plant extract - unclassified drug - withanolide - animal cell - antineoplastic activity - carbon nuclear magnetic resonance - conference paper - controlled study - jaborosa odonelliana
Descripción: From whole Jaborosa odonelliana plants four new withanolides containing a spiranic lactone in the side chain, were isolated and their structures elucidated by spectroscopic methods.
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Tettamanzi, M.C. - Veleiro, A.S. - De La Fuente, J.R. - Burton, G.
Molecules 2000;5(3):449-450
2000
Temas: carbon - plant extract - proton - salpichrolide - unclassified drug - withanolide - carbon nuclear magnetic resonance - chemical structure - conference paper - controlled study
Descripción: From the aerial parts of Salpichroa origanifolia a new withanolide in which the C-13 angular methyl has migrated to C-17, was isolated and characterized by spectroscopic methods.
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Bruttomesso, A.C. - Gros, E.G.
Molecules 2000;5(3):564-565
2000
Temas: (20) 3beta,16beta dihydroxy 5 pregnen 20,16 carbolactone - 3beta hydroxy 5 androsterone - alkaloid derivative - androsterone - diosgenin - hydroxyl group - lactone - sapogenin - steroid - unclassified drug
Descripción: Diosgeninlactone (1), a natural product from Solanum vespertilio, was stereo-selectively synthesized in high yield from 3β-hydroxy-5-androstene.
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Rosso, M.L. - Maier, M.S. - Bertoni, M.D.
Molecules 2000;5(3):345-347
2000
Temas: roridina a - roridina e - toxin - trichothecene - unclassified drug - verrucarina a - verrucarina j - Baccharis - Baccharis coridofolia - conference paper
Descripción: Cultures of the fungus epibiont from the herbaceous shrub B. coridifolia yielded four macrocyclic trichothecenes. As these toxins are the same as those found in B. coridifolia, the relationship between the plant and the epibiont must be considered as mutualistic.
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Paveto, C. - Güida, M.C. - Esteva, M.I. - Martino, V. - Coussio, J. - Flawiá, M.M. - Torres, H.N.
Antimicrob. Agents Chemother. 2004;48(1):69-74
2004
Temas: acetic acid ethyl ester - arginine kinase - catechin - catechin gallate - epicatechin - epicatechin gallate - epigallocatechin - epigallocatechin gallate - flavanol derivative - gallocatechin
Descripción: The trypanocidal action of green tea catechins against two different developmental stages of Trypanosoma cruzi is reported for the first time. This activity was assayed with the nonproliferative bloodstream trypomastigote and with the intracellular replicative amastigote parasite forms. An ethyl acetate fraction from Camellia sinensis green tea leaves, which contains most of the polyphenolic compounds and the maximal trypanocidal activity, was obtained by fractionation of the aqueous extract with organic solvents. The active compounds present in this extract were further purified by LH-20 column chromatography and were identified by high-performance liquid chromatography analysis with a photo diode array detector and gas chromatography coupled to mass spectroscopy. The following flavan-3-ols derivatives, known as catechins, were identified: catechin, epicatechin, gallocatechin, epigallocatechin, catechin gallate, epicatechin gallate, gallocatechin gallate, and epigallocatechin gallate. The purified compounds lysed more than 50% of the parasites present in the blood of infected BALB/c mice at concentrations as low as 0.12 to 85 pM. The most active compounds were gallocatechin gallate and epigallocatechin gallate, with minimal bactericidal concentrations that inhibited 50% of isolates tested of 0.12 and 0.53 pM, respectively. The number of amastigotes in infected Vero cells decreased by 50% in the presence of each of these compounds at 100 nM. The effects of the catechins on the recombinant T. cruzi arginine kinase, a key enzyme in the energy metabolism of the parasite, were assayed. The activity of this enzyme was inhibited by about 50% by nanomolar concentrations of catechin gallate or gallocatechin gallate, whereas the other members of the group were less effective. On the basis of these results, we suggest that these compounds could be used to sterilize blood and, eventually, as therapeutic agents for Chagas' disease.
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Perotti, C. - Fukuda, H. - DiVenosa, G. - MacRobert, A.J. - Batlle, A. - Casas, A.
Br. J. Cancer 2004;90(8):1660-1665
2004
Temas: ALA - ALA derivatives - Aminolevulinic acid - PDT - Photodynamic therapy - 2 (hydroxymethyl)tetrahydropyranyl 5 aminolevulinic acid - aminolevulinic acid - hexyl 5 aminolevulinic acid - photosensitizing agent - porphyrin
Descripción: The aim of this work was to test in vitro and in vivo the efficacy of the derivatives of 5-aminolevulinic acid (ALA): hexyl-ALA (He-ALA), undecanoyl-ALA and R,S-2-(hydroximethyl)tetrahydropyranyl-ALA (THP-ALA) as pro-photosensitising agents. The compounds were assayed in a cell line derived from a murine mammary tumour, in tumour explants and after injection of the cells into mice. In vitro, undecanoyl-ALA and THP-ALA did not improve ALA efficacy in terms of porphyrin synthesis. On the other hand, half of the amount of ALA is required to obtain the same plateau amount of photosensitiser from He-ALA. However, this plateau value cannot be surpassed in spite of the four-times higher accumulation of ALA/He-ALA from the ALA derivative. This shows that He-ALA conversion to porphyrins but not He-ALA entry to the cells is limiting. Employing ionic exchange chromatography, we found that 80% of total uptake was He-ALA whereas only 20% was ALA. This suggests that the esterases, probably themselves regulated by the heme pathway, are limiting the conversion of ALA derivatives into porphyrins. A similar situation occurs with THP-ALA. Tumour explant porphyrin results correlate well with cell line data. However, i.p. injection of ALA derivatives to mice resulted in a lower porphyrin concentration in the tumour when compared to the administration of equimolar amounts of ALA, indicating that there should be retention of ALA derivatives either within the blood vessels in the initial phase of distribution and/or within the capillaries of the tumour. © 2004 Cancer Research UK.
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Velikovsky, C.A. - Goldbaum, F.A. - Cassataro, J. - Estein, S. - Bowden, R.A. - Bruno, L. - Fossati, C.A. - Giambartolomei, G.H.
Infect. Immun. 2003;71(10):5750-5755
2003
Temas: aluminum hydroxide - Brucella vaccine - Freund adjuvant - gamma interferon - immunoglobulin G - immunoglobulin G antibody - immunoglobulin G1 - immunoglobulin G2 - interleukin 10 - interleukin 2
Descripción: The immunogenicity and protective efficacy of recombinant lumazine synthase from Brucella spp. (rBLS) administered with different adjuvants was evaluated in mice. Mice were immunized with rBLS in the absence or the presence of aluminum hydroxide gel (BLS-A1), monophosphoryl lipid A (BLS-MPA), or incomplete Freund's adjuvant (BLS-IFA). rBLS per se induced a vigorous immunoglobulin G (IgG) response, with high titers of IgG1 as well as IgG2. All the adjuvants increased this response; the BLS-IFA formulation was the most effective at inducing BLS-specific IgG antibodies. In addition, after in vitro stimulation with rBLS, spleen cells from BLS-IFA-, BLS-A1-, or BLS-MPA-immunized mice proliferated and produced interleukin-2 (IL-2), gamma interferon (IFN-γ), IL-10, and IL-4, suggesting the induction of a mixed Th1-Th2 response. Immunization with rBLS protected mice against challenge with B. abortus 544. The levels of protection in the spleen were similar for all adjuvants, but only BLS-A1 and BLS-IFA were effective in the liver. Our results indicate that BLS might be a useful candidate for the development of subunit vaccines against brucellosis, since it elicits antigen-specific cellular responses, with production of IFN-γ and protection, independently of the adjuvant formulation used.
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Brousse, B.N. - Moglioni, A.G. - Alho, M.M. - Álvarez-Larena, Á. - Moltrasio, G.Y. - D'Accorso, N.B.
Arkivoc 2002;2002(10):14-23
2002
Temas: Asymmetric spiro-heterocyclic compounds - Terpenones - Thiadiazolines - Thiosemicarbazones - 1,3,3 trimethyl 2 norcamphanone - camphor - heterocyclic compound - menthone - n [aza(1,7,7 trimethylbicyclo[2.2.1]hept 2 ylidene)methyl]acetamide - terpene derivative
Descripción: Preparation of chiral heterocyclic compounds of the thiadiazoline types, starting from natural terpenones such as fenchone, camphor and menthone, is described. Stereochemical assignment of the compounds synthesized was performed by NMR spectroscopy and X-ray analysis.
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Fraiman, D. - Pando, B. - Dargan, S. - Parker, I. - Dawson, S.P.
Biophys. J. 2006;90(11):3897-3907
2006
Temas: 1,4,5 triphosphate - calcium - phosphate - unclassified drug - animal cell - article - controlled study - dynamics - endoplasmic reticulum - fluorescence
Descripción: Puffs are localized Ca2+ signals that arise in oocytes in response to inositol 1,4,5-trisphosphate (IP3). They are analogous to the sparks of myocytes and are believed to be the result of the liberation of Ca2+ from the endoplasmic reticulum through the coordinated opening of IP3 receptor/channels clustered at a functional release site. In this article, we analyze sequences of puffs that occur at the same site to help elucidate the mechanisms underlying puff dynamics. In particular, we show a dependence of the interpuff time on the amplitude of the preceding puff, and of the amplitude of the following puff on the preceding interval. These relationships can be accounted for by an inhibitory role of the Ca2+ that is liberated during puffs. We construct a stochastic model for a cluster of IP3 receptor/channels that quantitatively replicates the observed behavior, and we determine that the characteristic time for a channel to escape from the inhibitory state is of the order of seconds. © 2006 by the Biophysical Society.
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Rosenfeldt, S. - Galati, B.G.
Biocell 2005;29(3):271-278
2005
Temas: Ontogeny - Oxalis - Pollen - Ubisch bodies - Ultrastructure - lipid - sporopollenin - unclassified drug - article - cell ultrastructure
Descripción: The correlation between the ontogeny of Ubisch bodies and pollen development in Oxalis articulata was studied with Transmission Electron Microscopy (TEM). The ultrastructural changes observed during the different stages of development in the tapetal cells are related to Ubisch bodies, sporopollenin and pollen-kitt formation. The pro-orbicules have the appearance of lipid globuli and their formation is related to the endoplasmic reticulum of rough type (ERr). The lipid globules or pro-orbicules disappear in the mature Ubisch bodies, and the places that they occupied remain free of contents or with pollen-kitt.
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