1 documento corresponde a la consulta.
Palabras contadas: dentate: 1, gyrus: 1
Moncada, D. - Ballarini, F. - Martinez, M.C. - Frey, J.U. - Viola, H.
Proc. Natl. Acad. Sci. U. S. A. 2011;108(31):12931-12936
2011
Temas: CA1 - Dentate gyrus - Synaptic tagging - beta adrenergic receptor - calcium calmodulin dependent protein kinase II - dopamine 1 receptor - dopamine 5 receptor - n methyl dextro aspartic acid receptor - neurotransmitter - animal experiment
Descripción: Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca 2+/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace.
...ver más Tipo de documento: info:ar-repo/semantics/artículo