Descripción: This paper discusses the general atmospheric circulation over Patagonia on the basis of the principal palaeoclimate forcings: continental drift, orography, variations in the greenhouse gases in the Earth's atmosphere, evolution of the atmosphere and the oceans, changes in the orbit of the Earth, albedo feedbacks, and the land surface. These processes affect climate on time scales of millions to hundreds of thousands of years. Additionally, orbital forcing has had a major influence on climate during the Quaternary. The palaeo-atmospheric circulation of Patagonia is analyzed for the Early to Late Jurassic, the Cretaceous, the Late Palaeocene-Eocene Thermal Maximum, the Tortonian-Oligocene cooling, the Pliocene, the Quaternary including the Last Glacial Maximum, the Holocene Optimum, and the last millennium changes. Alternative palaeo-atmospheric circulations from climatic modelling scenarios through the ages are reviewed and compared with proxy data. Detailed and updated reference information on the topics analyzed is also provided. © 2011 The Linnean Society of London.