Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease

Urbina, J.A. - Concepcion, J.L. - Montalvetti, A. - Rodriguez, J.B. - Docampo, R.

En:

Antimicrob. Agents Chemother. 2003;47(6):2047-2050

Fecha:

2003

Formato:

application/pdf

Tipo de documento:

info:eu-repo/semantics/article
info:ar-repo/semantics/artículo
info:eu-repo/semantics/publishedVersion

Descriptores:

4 phenoxyphenoxyethyl thiocyanate - antiprotozoal agent - squalene synthase - sterol - unclassified drug - wc 9 - antiprotozoal activity - article - Chagas disease

Descripción:

We investigated the molecular basis of the activity of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the etiological agent of Chagas' disease. We found that growth inhibition of T. cruzi epimastigotes induced by this compound was associated with a reduction in the content of the parasite's endogenous sterols due to a specific blockade of their de novo synthesis at the level of squalene synthase.
Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.

Identificador(es):

http://hdl.handle.net/20.500.12110/paper_00664804_v47_n6_p2047_Urbina

Derechos:

info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/2.5/ar

Descargar texto: paper_00664804_v47_n6_p2047_Urbina.oai

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Cita bibliográfica:

Urbina, J.A. (2003). Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease (info:eu-repo/semantics/article). [consultado: ] Disponible en el Repositorio Digital Institucional de la Universidad de Buenos Aires: <http://repositoriouba.sisbi.uba.ar/gsdl/cgi-bin/library.cgi?a=d&c=artiaex&cl=CL1&d=paper_00664804_v47_n6_p2047_Urbina_oai>