Acilación quimioselectiva de hidroxialcanotioles catalizada por lipasas en medio orgánico

Institución otorgante:

Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales

Fecha:

1996

Tipo de documento: 

info:eu-repo/semantics/doctoralThesis
 

Formato:

application/pdf

Idioma:

spa

Temas:

LIPASES - ORGANIC MEDIA - HYDROXYALKANETHIOLS - SELECTIVE ACYLATION - TRANSESTERIFICATION

Descripción:

Various bi- and polifunctional hydroxyalkanethiols were chemospecificallyacylated to O-acylesters by lipase-catalyzed transesterifications in organic media. Inaddition, hydroxyalkanethiols with two hydroxyl groups exhibited regiospecificity orregioselectivity, depending on the nature of both the substrate and the lipase. As the chainlength of the α,ω-hydroxyalkanethiol increased, the reaction was limited to smaller acylmoieties. Experimental conditions under which enzymatic acylations were carried out andtheir results are presented and discussed. Biocatalyzed transesterifications allowed thepreparation of twenty-four new esters. The preparation of some α,ω-hydroxyalkanethiolsand the mass spectra of substrates and products are also presented and discussed.

Identificador:

https://hdl.handle.net/20.500.12110/tesis_n2856_Iglesias